Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs

Østensen, M; Lockshin, M; Doria, A; Valesini, G; Meroni, P; Gordon, C; Brucato, A; Tincani, A (2008). Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs. Rheumatology, 47 Suppl 3, iii28-31. Oxford: Oxford University Press 10.1093/rheumatology/ken168

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A consensus paper concerning the interaction of anti-rheumatic drugs and reproduction was published in 2006, representing data collected during the year 2004 and 2005. Because of an increasing use of biological agents in women of fertile age, the information was updated for the years 2006 and 2007. Experts disagree whether TNF-inhibitors should be stopped as soon as pregnancy is recognized or may be continued throughout pregnancy. Pregnancy experience with abatacept and rituximab is still too limited to prove their safety for the developing fetus. They must be withdrawn before a planned pregnancy. LEF has not been proven to be a human teratogen. Registries of transplant recipients have shown that cyclosporin (CsA) and tacrolimus do not increase the rate of congenital anomalies, whereas mycophenolate mofetil (MMF) clearly carries a risk for congenital anomalies. Prophylactic withdrawal of drugs before pregnancy is mandatory for abatacept, rituximab, LEF and MMF. Data remain insufficient for gonadal toxicity of immunosuppressive drugs in men and for excretion of these drugs in human breast milk.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Oestensen, Monika Elisabeth

ISSN:

1462-0324

ISBN:

18504282

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

26 Oct 2019 19:41

Publisher DOI:

10.1093/rheumatology/ken168

PubMed ID:

18504282

Web of Science ID:

000257851100009

BORIS DOI:

10.7892/boris.27510

URI:

https://boris.unibe.ch/id/eprint/27510 (FactScience: 108184)

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