Developmental alveolarization of the mouse lung

Mund, Sonja I; Stampanoni, Marco; Schittny, Johannes C (2008). Developmental alveolarization of the mouse lung. Developmental dynamics, 237(8), pp. 2108-16. New York, N.Y.: John Wiley & Sons 10.1002/dvdy.21633

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Postnatal lung development is not well characterized in mice, especially the time point when alveolarization is completed. Using the total length and the length density of the free septal edge as measured for the formation of new septa, we followed alveolarization throughout postnatal lung development (days 2-125). Furthermore, the alveolar surface area was estimated. The formation of new septa was observed until day 36. Approximately 10% of the septa present in adult mice were formed prenatally by branching morphogenesis, approximately 50% were generated postnatally before and approximately 40% after maturation of the alveolar microvasculature. Approximately 5% of the alveolar surface area present during adulthood was present before alveolarization started, approximately 55% was formed during alveolarization (days 4-36) and approximately 40% afterward due to growth processes. We conclude that alveolarization continues until young adulthood and that the maturation of the alveolar microvasculature does not preclude further alveolarization.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy
UniBE Contributor:	Mund, Sonja, Schittny, Johannes
ISSN:	1058-8388
ISBN:	18651668
Publisher:	John Wiley & Sons
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:03
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1002/dvdy.21633
PubMed ID:	18651668
Web of Science ID:	000258482300018
URI:	https://boris.unibe.ch/id/eprint/27531 (FactScience: 108746)