Cathepsins: key modulators of cell death and inflammatory responses

Conus, Sébastien; Simon, Hans-Uwe (2008). Cathepsins: key modulators of cell death and inflammatory responses. Biochemical pharmacology, 76(11), pp. 1374-82. New York, N.Y.: Elsevier 10.1016/j.bcp.2008.07.041

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Apoptosis is a key mechanism in the build up and maintenance of both innate and adaptive immunity as well as in the regulation of cellular homeostasis in almost every organ and tissue. Central to the apoptotic process is a family of intracellular cysteine proteases with aspartate-specificity, called caspases. Nevertheless, there is growing evidence that other non-caspase proteases, in particular lysosomal cathepsins, can play an important role in the regulation of apoptosis. In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

ISSN:

0006-2952

ISBN:

18762176

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1016/j.bcp.2008.07.041

PubMed ID:

18762176

Web of Science ID:

000261569400008

URI:

https://boris.unibe.ch/id/eprint/27534 (FactScience: 108752)

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