Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice

Goering, W; Adham, I M; Pasche, B; Manner, J; Ochs, M; Engel, W; Zoll, B (2008). Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice. Cytogenetic and genome research, 121(2), pp. 88-95. Basel: Karger 10.1159/000125833

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The mouse Foxq1 gene, also known as Hfh1, encodes a winged helix/forkhead transcription factor. In adult mice, Foxq1 is highly expressed in kidney and stomach. Here, we report that Foxq1 is expressed during prenatal and postnatal stomach development and the transcripts are restricted to acid secreting parietal cells. Mice homozygous for a deletion of the Foxq1 locus on a 129/Sv x C57BL/6J hybrid genetic background display variable phenotypes consistent with requirement of the gene during embryogenesis. Approximately 50% of Foxq1-/- embryos die in utero. Surviving homozygous mutants are normal and fertile, and have a silky shiny coat. Although the parietal cell development is not affected in the absence of Foxq1, there is a lack of gastric acid secretion in response to various secretagogue stimuli. Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Ochs, Matthias

ISSN:

1424-8581

ISBN:

18544931

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

17 Mar 2015 22:17

Publisher DOI:

10.1159/000125833

PubMed ID:

18544931

Web of Science ID:

000256880300002

URI:

https://boris.unibe.ch/id/eprint/27563 (FactScience: 108855)

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