High-dose intravenous corticosteroid pulse therapy in alopecia areata: own experience compared with the literature

Luggen, Peter; Hunziker, Thomas (2008). High-dose intravenous corticosteroid pulse therapy in alopecia areata: own experience compared with the literature. Journal der Deutschen Dermatologischen Gesellschaft, 6(5), pp. 375-8. Berlin: Blackwell 10.1111/j.1610-0387.2007.06608.x

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BACKGROUND: Seven prospective studies including 193 patients have been published on high-dose intravenous corticosteroid pulse therapy in alopecia areata (AA).We compare these data with a retrospective analysis of our own consecutive patients. PATIENTS AND METHODS: Between 1998 and 2002,25 patients with severe AA were treated at the Department of Dermatology, University of Bern, with infusions of 500 mg methylprednisolone on 3 consecutive days.In addition to the inpatient records, in 2004 all patients were followed up by a questionnaire. RESULTS: Four of 10 patients with multifocal AA and 3 of 9 patients with ophiasis-type AA had full re-growth of hair, whereas all 6 patients with AA totalis/universalis failed to respond. CONCLUSION: Intravenous corticosteroid pulse therapy may be helpful in the treatment of multifocal and ophiasis-type AA. Patients with an initial episode of short duration have better chances for success.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
UniBE Contributor:	Hunziker, Thomas
ISSN:	1610-0379
ISBN:	18205838
Publisher:	Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:04
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1111/j.1610-0387.2007.06608.x
PubMed ID:	18205838
Web of Science ID:	000255839700006
URI:	https://boris.unibe.ch/id/eprint/27637 (FactScience: 109751)