First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia

Baumann, Marc U; Bersinger, Nick A; Mohaupt, Markus G; Raio, Luigi; Gerber, Susan; Surbek, Daniel V (2008). First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia. American journal of obstetrics and gynecology, 199(3), 266.e1-6. Orlando, Fla.: Elsevier 10.1016/j.ajog.2008.06.069

Full text not available from this repository. (Request a copy)

OBJECTIVE: The aim of this investigation was to assess soluble endoglin (sEng) and soluble fms-like tyrosine kinase-1 (sFlt1) as first-trimester serum markers to predict preeclampsia. STUDY DESIGN: First-trimester sera were obtained from 46 women with subsequent late-onset preeclampsia and from 92 controls. sEng and sFlt1 concentrations were determined immunoanalytically. Correlation analysis with inhibin A and placental growth factor levels was performed. RESULTS: sEng and sFlt1 serum concentrations were higher in women with subsequent preeclampsia than in controls (mean +/- SD, sEng: 5.57 +/- 1.18 ng/mL vs 5.02 +/- 1.01 ng/mL, P = .009; sFlt1: 1764 +/- 757 pg/mL vs 1537 +/- 812 pg/mL, P = .036). Sensitivities and specificities for predicting preeclampsia were 63% and 57% for sEng and 64% and 56% for sFlt1, respectively. When sEng and inhibin A were combined, the sensitivity increased to 68%, whereas the specificity was 61%. CONCLUSION: sEng and sFlt1 are increased in the first trimester in women with subsequent late-onset preeclampsia and might therefore prove useful to predict preeclampsia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

Baumann, Marc; Bersinger, Nick A.; Mohaupt, Markus; Raio, Luigi; Gerber, Susan Charlotte and Surbek, Daniel

ISSN:

0002-9378

ISBN:

18771978

Publisher:

Elsevier

Language:

English

Submitter:

Markus Georg Mohaupt

Date Deposited:

04 Oct 2013 15:04

Last Modified:

26 Feb 2014 04:37

Publisher DOI:

10.1016/j.ajog.2008.06.069

PubMed ID:

18771978

Web of Science ID:

000258955400019

URI:

https://boris.unibe.ch/id/eprint/27851 (FactScience: 112885)

Actions (login required)

Edit item Edit item
Provide Feedback