Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women

Dedes, Konstantin J; Beneder, Christine; Samartzis, Nicolas; Muller, Michael D; Fink, Daniel; Fehr, Mathias K (2008). Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women. Journal of reproductive medicine, 53(12), pp. 947-51. St. Louis, Mo.: Science Printers & Publishers

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OBJECTIVE: To determine characteristics and clinical course of high-grade anogenital intraepithelial neoplasia (AIN) in human immunodeficiency virus (HIV)-infected women. STUDY DESIGN: HIV-positive women with biopsy-proven high-grade (II and III) vulvar (VIN), vaginal (VAIN) or perianal intraepithelial neoplasia (PAIN) were identified in the electronic databases of 2 colposcopy clinics. RESULTS: A total of 31 patients were identified from 1992 to 2007, of which 30 had a mean follow-up of 47.7 months (SD = 46.0; range, 2.6-166.2). Of the patients, 77.4% had VIN, 12.9% VAIN and 9.7% PAIN at first diagnosis. Age at diagnosis of IN was 36.2 years (SD +/- 5.2; range, 23.5-47.0). Ninety percent of patients received antiretroviral therapy at first diagnosis of IN; 65% (13 of 20) of patients with a follow-up of > 2 years required a second treatment, and 2 developed invasive vulvar cancer (10%). CONCLUSION: AIN among HIV-positive women shows a high relapse rate despite treatment modality used and a substantial invasive potential.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Beneder, Christine and Mueller, Michael

ISSN:

0024-7758

ISBN:

19160654

Publisher:

Science Printers & Publishers

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

04 May 2014 23:19

PubMed ID:

19160654

Web of Science ID:

000261748000007

URI:

https://boris.unibe.ch/id/eprint/27853 (FactScience: 112935)

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