A pilot study of Connexin 43 (Cx43) in human bladder tissue in patients with idiopathic detrusor overactivity

Kuhn, Annette; Stadlmayr, Werner; Monga, Ash; Cameron, Ian; Anthony, Fred (2008). A pilot study of Connexin 43 (Cx43) in human bladder tissue in patients with idiopathic detrusor overactivity. European journal of obstetrics & gynecology and reproductive biology, 141(1), pp. 83-6. Shannon: Elsevier 10.1016/j.ejogrb.2008.06.002

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OBJECTIVE: Aim of the study was to compare Connexin 43 (Cx43) in human bladder tissue of urodynamically proven idiopathic detrusor overactivity to those of urodynamically stable bladders. STUDY DESIGN: We compared bladder biopsies of patients with detrusor overactivity and those with stable bladder analysing Cx43 message by RNA extraction and PCR amplification. All patients had multichannel urodynamics prior to the biopsies. RESULTS: We investigated the bladder biopsies of 15 female patients with and 15 patients without detrusor overactivity. Cx43 could be detected in nine patients of the detrusor overactivity group and in eight patients of the control group which was not statistically significant. 42 cycles of PCR were necessary to demonstrate Cx43 presence in the positive specimen. The presence of Cx43 was not consistent in the samples from the bladder dome and the side walls meaning there were Cx43 positive results in the dome and negative ones in the side walls of the same patient and vice versa. CONCLUSION: In conclusion, Cx43 is present in human bladder tissue both of overactive bladders and those of controls. However, it is expressed in very small amounts and is not always detectable. The role of Cx43 for the origin of detrusor overactivity remains unclear.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Kuhn, Annette and Stadlmayr, Werner

ISSN:

0301-2115

ISBN:

18687515

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1016/j.ejogrb.2008.06.002

PubMed ID:

18687515

Web of Science ID:

000261297800019

URI:

https://boris.unibe.ch/id/eprint/27868 (FactScience: 113029)

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