The role of lymphadenectomy in high risk prostate cancer

Burkhard, Fiona C; Studer, Urs E (2008). The role of lymphadenectomy in high risk prostate cancer. World journal of urology, 26(3), pp. 231-6. Berlin: Springer-Verlag 10.1007/s00345-008-0251-6

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Historically, patients with high risk prostate cancer were considered poor candidates for radical prostatectomy (RP) due to the likelihood of positive pelvic lymph nodes and decreased long term survival. Although there is still no consensus on the optimal therapy for this group of patients, there is increasing evidence that surgery could play a role. Cancer specific survival (CSS) rates after RP for locally advanced disease at 10 year follow up range from 29 to 72%, depending on tumor differentiation. The role of pelvic lymph node dissection (PLND) in prostate cancer remains a controversial topic. Nonetheless, in conjunction with RRP extended PLND (ePLND) should be performed as extended lymph node dissection in lieu of standard PLND may increase staging accuracy, influence decision making with respect to adjuvant therapy and possibly impact outcome. High risk patients with organ confined prostate cancer and low volume (micro)metastatic disease may be the ones to profit most from this approach.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Burkhard, Fiona C. and Studer, Urs

ISSN:

0724-4983

ISBN:

18369636

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

26 Jun 2018 13:51

Publisher DOI:

10.1007/s00345-008-0251-6

PubMed ID:

18369636

Web of Science ID:

000256092300006

BORIS DOI:

10.7892/boris.27987

URI:

https://boris.unibe.ch/id/eprint/27987 (FactScience: 115399)

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