Stucki, Armin; Gerber, Peter; Acosta, Fernando; Cottagnoud, Marianne; Cottagnoud, Philippe; Jiang, Lijiang; Nguyen, Phong; Wachtel, Derek; Wang, Guoqiang; Phan, Ly T (2008). Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 61(3), pp. 665-9. Oxford: Oxford University Press 10.1093/jac/dkm505
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OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin-resistant and a penicillin- and quinolone-resistant mutant. EDP-420 was also tested against both strains in time-killing assays over 8 h in vitro. RESULTS: In experimental meningitis, EDP-420 produced a bactericidal activity comparable to the standard regimen based on a combination of vancomycin with ceftriaxone against a penicillin-resistant Streptococcus pneumoniae and a penicillin- and quinolone-resistant S. pneumoniae isolate. The penetration of EDP-420 into inflamed meninges was 38% after an i.v. injection of 10 mg/kg. The bactericidal activity of EDP-420 was also confirmed in in vitro time-killing assays. CONCLUSIONS: EDP-420 is an efficacious alternative treatment in pneumococcal meningitis, especially when resistant strains are suspected.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
?? DCD5A442B9C7E17DE0405C82790C4DE2 ?? 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology |
UniBE Contributor: |
Stucki, Armin Niklaus, Gerber, Peter |
ISSN: |
0305-7453 |
ISBN: |
18222952 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:04 |
Last Modified: |
21 Feb 2023 15:28 |
Publisher DOI: |
10.1093/jac/dkm505 |
PubMed ID: |
18222952 |
Web of Science ID: |
000253490800030 |
BORIS DOI: |
10.7892/boris.28062 |
URI: |
https://boris.unibe.ch/id/eprint/28062 (FactScience: 116243) |
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