Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model

Stucki, Armin; Gerber, Peter; Acosta, Fernando; Cottagnoud, Marianne; Cottagnoud, Philippe; Jiang, Lijiang; Nguyen, Phong; Wachtel, Derek; Wang, Guoqiang; Phan, Ly T (2008). Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 61(3), pp. 665-9. Oxford: Oxford University Press 10.1093/jac/dkm505

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OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin-resistant and a penicillin- and quinolone-resistant mutant. EDP-420 was also tested against both strains in time-killing assays over 8 h in vitro. RESULTS: In experimental meningitis, EDP-420 produced a bactericidal activity comparable to the standard regimen based on a combination of vancomycin with ceftriaxone against a penicillin-resistant Streptococcus pneumoniae and a penicillin- and quinolone-resistant S. pneumoniae isolate. The penetration of EDP-420 into inflamed meninges was 38% after an i.v. injection of 10 mg/kg. The bactericidal activity of EDP-420 was also confirmed in in vitro time-killing assays. CONCLUSIONS: EDP-420 is an efficacious alternative treatment in pneumococcal meningitis, especially when resistant strains are suspected.

Item Type:

Journal Article (Original Article)

Division/Institute:

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04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Stucki, Armin Niklaus and Gerber, Peter

ISSN:

0305-7453

ISBN:

18222952

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

27 Apr 2018 09:50

Publisher DOI:

10.1093/jac/dkm505

PubMed ID:

18222952

Web of Science ID:

000253490800030

BORIS DOI:

10.7892/boris.28062

URI:

https://boris.unibe.ch/id/eprint/28062 (FactScience: 116243)

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