Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis

Ingueneau, Cécile; Huynh-Do, Uyen; Thiers, Jean-Claude; Nègre-Salvayre, Anne; Salvayre, Robert; Vindis, Cécile (2008). Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis. Biochemical and biophysical research communications, 369(3), pp. 889-93. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2008.02.134

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Oxidized low-density lipoprotein (oxLDL)-induced apoptosis of vascular cells may participate to plaque instability and rupture. Caveolin-1 has emerged as an important regulator of several signal transduction pathways and processes that play a role in atherosclerosis. In this study we examined the potential role of caveolin-1 in the regulation of oxLDL-induced Ca(2+) signaling and apoptosis in vascular smooth muscle cells (VSMC). Cells expressing caveolin-1 were more susceptible to oxLDL-induced apoptosis, and this was correlated with enhanced Ca(2+) entry and pro-apoptotic events. Moreover, caveolin-1 silencing by small interfering RNA decreased the level of apoptotic cells after oxLDL treatment. These findings provide new insights about the potential role of caveolin-1 in the regulation of oxLDL-induced apoptosis in vascular cells and its contribution to the instability of the plaque.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Huynh-Do, Uyen
ISSN:	0006-291X
ISBN:	18328807
Publisher:	Academic Press
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:05
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.1016/j.bbrc.2008.02.134
PubMed ID:	18328807
Web of Science ID:	000254846500019
URI:	https://boris.unibe.ch/id/eprint/28096 (FactScience: 116596)