Perivascular spaces and the two steps to neuroinflammation

Owens, Trevor; Bechmann, Ingo; Engelhardt, Britta (2008). Perivascular spaces and the two steps to neuroinflammation. Journal of neuropathology and experimental neurology, 67(12), pp. 1113-21. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e31818f9ca8

Full text not available from this repository. (Request a copy)

Immune cells enter the central nervous system (CNS) from the circulation under normal conditions for immunosurveillance and in inflammatory neurologic diseases. This review describes the distinct anatomic features of the CNS vasculature that permit it to maintain parenchymal homeostasis and which necessitate specific mechanisms for neuroinflammation to occur. We review the historical evolution of the concept of the blood-brain barrier and discuss distinctions between diffusion/transport of solutes and migration of cells from the blood to CNS parenchyma. The former is regulated at the level of capillaries, whereas the latter takes place in postcapillary venules. We summarize evidence that entry of immune cells into the CNS parenchyma in inflammatory conditions involves 2 differently regulated steps: transmigration of the vascular wall into the perivascular space and progression across the glia limitans into the parenchyma.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta






Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:


PubMed ID:


Web of Science ID:


URI: (FactScience: 118480)

Actions (login required)

Edit item Edit item
Provide Feedback