Perivascular spaces and the two steps to neuroinflammation

Owens, Trevor; Bechmann, Ingo; Engelhardt, Britta (2008). Perivascular spaces and the two steps to neuroinflammation. Journal of neuropathology and experimental neurology, 67(12), pp. 1113-21. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e31818f9ca8

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Immune cells enter the central nervous system (CNS) from the circulation under normal conditions for immunosurveillance and in inflammatory neurologic diseases. This review describes the distinct anatomic features of the CNS vasculature that permit it to maintain parenchymal homeostasis and which necessitate specific mechanisms for neuroinflammation to occur. We review the historical evolution of the concept of the blood-brain barrier and discuss distinctions between diffusion/transport of solutes and migration of cells from the blood to CNS parenchyma. The former is regulated at the level of capillaries, whereas the latter takes place in postcapillary venules. We summarize evidence that entry of immune cells into the CNS parenchyma in inflammatory conditions involves 2 differently regulated steps: transmigration of the vascular wall into the perivascular space and progression across the glia limitans into the parenchyma.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

0022-3069

ISBN:

19018243

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1097/NEN.0b013e31818f9ca8

PubMed ID:

19018243

Web of Science ID:

000261352100001

URI:

https://boris.unibe.ch/id/eprint/28188 (FactScience: 118480)

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