Strategies to advance translational research into brain barriers

Neuwelt, Edward; Abbott, N Joan; Abrey, Lauren; Banks, William A; Blakley, Brian; Davis, Thomas; Engelhardt, Britta; Grammas, Paula; Nedergaard, Maiken; Nutt, John; Pardridge, William; Rosenberg, Gary A; Smith, Quentin; Drewes, Lester R (2008). Strategies to advance translational research into brain barriers. Lancet neurology, 7(1), pp. 84-96. Oxford: Elsevier 10.1016/S1474-4422(07)70326-5

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There is a paucity of therapies for most neurological disorders--from rare lysosomal storage diseases to major public health concerns such as stroke and Alzheimer's disease. Advances in the targeting of drugs to the CNS are essential for the future success of neurotherapeutics; however, the delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by the blood-brain barrier, the blood-CSF barrier, or other specialised CNS barriers. These brain barriers are now recognised as a major obstacle to the treatment of most brain disorders. The challenge to deliver therapies to the CNS is formidable, and the solution will require concerted international efforts among academia, government, and industry. At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

1474-4422

ISBN:

18093565

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

17 Mar 2015 22:19

Publisher DOI:

10.1016/S1474-4422(07)70326-5

PubMed ID:

18093565

Web of Science ID:

000252063300029

URI:

https://boris.unibe.ch/id/eprint/28199 (FactScience: 118502)

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