Stem cells as tools in regenerative therapy for retinal degeneration

Enzmann, Volker; Yolcu, Esma; Kaplan, Henry J; Ildstad, Suzanne T (2009). Stem cells as tools in regenerative therapy for retinal degeneration. Archives of ophthalmology, 127(4), pp. 563-71. Chicago, Ill.: American Medical Association 10.1001/archophthalmol.2009.65

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OBJECTIVE: To describe the use of stem cells (SCs) for regeneration of retinal degenerations. Regenerative medicine intends to provide therapies for severe injuries or chronic diseases where endogenous repair does not sufficiently restore the tissue. Pluripotent SCs, with their capacity to give rise to specialized cells, are the most promising candidates for clinical application. Despite encouraging results, a combination with up-to-date tissue engineering might be critical for ultimate success. DESIGN: The focus is on the use of SCs for regeneration of retinal degenerations. Cell populations include embryonic, neural, and bone marrow-derived SCs, and engineered grafts will also be described. RESULTS: Experimental approaches have successfully replaced damaged photoreceptors and retinal pigment epithelium using endogenous and exogenous SCs. CONCLUSIONS: Stem cells have the potential to significantly impact retinal regeneration. A combination with bioengineering may bear even greater promise. However, ethical and scientific issues have yet to be solved.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Enzmann, Volker

ISSN:

0003-9950

ISBN:

19365041

Publisher:

American Medical Association

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1001/archophthalmol.2009.65

PubMed ID:

19365041

Web of Science ID:

000265103400031

URI:

https://boris.unibe.ch/id/eprint/28231 (FactScience: 118931)

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