A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography

Fischer, M Dominik; Fleischhauer, Johannes C; Gillies, Mark C; Sutter, Florian K; Helbig, Horst; Barthelmes, Daniel (2008). A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography. Investigative ophthalmology & visual science, 49(8), pp. 3617-21. Hagerstown, Md.: Association for Research in Vision and Ophthalmology 10.1167/iovs.08-2003

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PURPOSE: To correlate the dimension of the visual field (VF) tested by Goldman kinetic perimetry with the extent of visibility of the highly reflective layer between inner and outer segments of photoreceptors (IOS) seen in optical coherence tomography (OCT) images in patients with retinitis pigmentosa (RP). METHODS: In a retrospectively designed cross-sectional study, 18 eyes of 18 patients with RP were examined with OCT and Goldmann perimetry using test target I4e and compared with 18 eyes of 18 control subjects. A-scans of raw scan data of Stratus OCT images (Carl Zeiss Meditec, AG, Oberkochen, Germany) were quantitatively analyzed for the presence of the signal generated by the highly reflective layer between the IOS in OCT images. Starting in the fovea, the distance to which this signal was detectable was measured. Visual fields were analyzed by measuring the distance from the center point to isopter I4e. OCT and visual field data were analyzed in a clockwise fashion every 30 degrees , and corresponding measures were correlated. RESULTS: In corresponding alignments, the distance from the center point to isopter I4e and the distance to which the highly reflective signal from the IOS can be detected correlate significantly (r = 0.75, P < 0.0001). The greater the distance in VF, the greater the distance measured in OCT. CONCLUSIONS: The authors hypothesize that the retinal structure from which the highly reflective layer between the IOS emanates is of critical importance for visual and photoreceptor function. Further research is warranted to determine whether this may be useful as an objective marker of progression of retinal degeneration in patients with RP.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
UniBE Contributor:	Fleischhauer, Johannes M.C., Barthelmes, Daniel
ISSN:	0146-0404
ISBN:	18441301
Publisher:	Association for Research in Vision and Ophthalmology
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:05
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.1167/iovs.08-2003
PubMed ID:	18441301
Web of Science ID:	000257951100048
URI:	https://boris.unibe.ch/id/eprint/28237 (FactScience: 118962)