Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome

Schlapbach, Luregn Jan; Riedel, Thomas; Genitsch, Vera; Nelle, Mathias; McDougall, Felicity Jane (2010). Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome. Pediatrics, 126(2), e483-7. Elk Grove Village, Ill.: American Academy of Pediatrics 10.1542/peds.2009-3490

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Thrombotic events are being increasingly recognized during the neonatal period. An infant girl was born at 29 weeks' gestation after a pregnancy complicated by twin-to-twin transfusion syndrome. After an initial uncomplicated clinical course, her oxygen requirement increased, which was interpreted as an early sign of bronchopulmonary dysplasia. At 3 weeks of age, she suddenly collapsed and died of severe pulmonary hypertension. At autopsy, multiple pulmonary artery emboli and several older renal vein thromboses were found. Results of genetic analyses of the infant and her family were negative for thrombophilia. Although embolism represents a frequent emergency in adults, fatal pulmonary embolism has never, to our knowledge, been described for premature infants. This case suggests that thrombotic events are underdiagnosed and that additional studies are needed to define infants at risk and optimal treatment strategies.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Schlapbach, Luregn Jan; Riedel, Thomas; Genitsch Gratwohl, Vera and Nelle, Mathias




American Academy of Pediatrics




Anette van Dorland

Date Deposited:

04 Oct 2013 14:13

Last Modified:

20 Jul 2022 10:02

Publisher DOI:


PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/2828 (FactScience: 205748)

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