Different anticoagulation strategies in off-pump coronary artery bypass operations: a European survey

Englberger, Lars; Streich, Marianne; Tevaearai, Hendrik; Carrel, Thierry P (2008). Different anticoagulation strategies in off-pump coronary artery bypass operations: a European survey. Interactive cardiovascular and thoracic surgery, 7(3), pp. 378-82. Oxford: Oxford University Press

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In order to determine anticoagulation strategies in OPCAB a questionnaire survey among 750 European cardio-thoracic surgeons was performed. Questions addressed volume of OPCAB procedures performed, intra- and perioperative heparinization and antiplatelet therapy, as well as perioperative management. A total of 325 (43.7%) questionnaires were returned and validated. Perioperative protocols for administration of antiplatelets differed among the respondent surgeons. Perioperative prophylaxis of thrombosis (low or high molecular weight heparin) is performed by 78%. Intraoperative heparin dosage range between 70 U/kg to 500 U/kg, 60% of respondents prefer a low-dose regimen (< or = 150 U/kg). Correspondingly, the lowest activated clotting time (ACT) during surgery is accepted to be 200 s by 24%, 250 s by 18% and 300 s by 26% of surgeons. Protamine is used by 91% of respondents, while 52% perform a 1:1 reversal. A cell-saver and antifibrinolytics are used by 70% and 40%, respectively. Interestingly, 56% of respondents think bleeding in OPCAB patients is not reduced when compared to on-pump CABG. In addition, 34% of respondents believe there is an increased risk of early graft occlusion following OPCAB. This survey demonstrates widely different intra- and perioperative anticoagulation strategies for OPCAB procedures among European surgeons.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery

UniBE Contributor:

Englberger, Lars, Tevaearai, Hendrik, Carrel, Thierry






Oxford University Press




Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

27 Feb 2024 14:29

PubMed ID:



https://boris.unibe.ch/id/eprint/28280 (FactScience: 119536)

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