New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima

Collu, Francesca; Bonsignore, Leonardo; Casu, Mariano; Floris, Costantino; Gertsch, Jürg; Cottiglia, Filippo (2008). New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima. Bioorganic and medicinal chemistry letters, 18(5), pp. 1559-62. New York, N.Y.: Pergamon 10.1016/j.bmcl.2008.01.078

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Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC(50) values ranging from 3.2 to 14 microM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Gertsch, Jürg

ISSN:

0960-894X

ISBN:

18262418

Publisher:

Pergamon

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1016/j.bmcl.2008.01.078

PubMed ID:

18262418

Web of Science ID:

000254180200003

URI:

https://boris.unibe.ch/id/eprint/28331 (FactScience: 120067)

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