Combined approach to hepatocellular carcinoma: a new treatment concept for nonresectable disease

Strebel, Bruno M; Dufour, Jean-François (2008). Combined approach to hepatocellular carcinoma: a new treatment concept for nonresectable disease. Expert review of anticancer therapy, 8(11), pp. 1743-9. London: Expert Reviews 10.1586/14737140.8-11.1743

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Depending on tumor burden, hepatic function and patients' performance status, hepatocellular carcinoma is treated by surgery, local procedures, systemic therapy or palliation. The majority of patients are diagnosed at a stage where local therapy is the treatment of choice. Recently, the multikinase inhibitor sorafenib was found to improve the survival of patients with advanced hepatocellular carcinoma and conserved liver function. In this manuscript, we summarize the experimental evidence supporting the combination of a systemic targeted therapy with a local therapy. We also discuss the pros and cons of different schedules of combining such treatments. We conclude that there is enough of a theoretical argument to design clinical trials testing this strategy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Strebel, Bruno Michael and Dufour, Jean-François

ISSN:

1473-7140

ISBN:

18983234

Publisher:

Expert Reviews

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1586/14737140.8-11.1743

PubMed ID:

18983234

Web of Science ID:

000261050100004

URI:

https://boris.unibe.ch/id/eprint/28358 (FactScience: 120272)

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