Tumor suppressor and hepatocellular carcinoma

Martin, Juliette; Dufour, Jean-François (2008). Tumor suppressor and hepatocellular carcinoma. World journal of gastroenterology, 14(11), pp. 1720-33. Beijing (China): WJG Press 10.3748/wjg.14.1720

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A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research (discontinued)

UniBE Contributor:

Martin, Juliette and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1007-9327

ISBN:

18350603

Publisher:

WJG Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

10 Oct 2016 19:57

Publisher DOI:

10.3748/wjg.14.1720

PubMed ID:

18350603

Web of Science ID:

000255718500012

URI:

https://boris.unibe.ch/id/eprint/28360 (FactScience: 120276)

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