Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation

Chan, Yee-Cheun; Burgunder, Jean-Marc; Wilder-Smith, Einar; Chew, Soh-Eng; Lam-Mok-Sing, Karen M J; Sharma, Vijay; Ong, Benjamin K C (2008). Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. Journal of clinical neuroscience, 15(8), pp. 891-4. Amsterdam: Elsevier 10.1016/j.jocn.2007.01.013

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The S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on electroencephalography during hemiplegic migraine attacks. Depressed activity contralateral to the hemiparesis was seen on electroencephalography during acute hemiplegic migraine attacks, which may be due to changes to calcium channels caused by the S218L mutation. Both parents were asymptomatic and did not carry the S218L mutation in their blood. This suggests the presence of mosaicism in the transmitting parent.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Burgunder, Jean-Marc

ISSN:

0967-5868

ISBN:

18313928

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1016/j.jocn.2007.01.013

PubMed ID:

18313928

Web of Science ID:

000257868600008

URI:

https://boris.unibe.ch/id/eprint/28379 (FactScience: 120478)

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