Thalamic stimulation for tremor. Subtle changes in episodic memory are related to stimulation per se and not to a microthalamotomy effect

Loher, Thomas J; Gutbrod, Klemens; Fravi, Nina L; Pohle, Thomas; Burgunder, Jean-Marc; Krauss, Joachim K (2003). Thalamic stimulation for tremor. Subtle changes in episodic memory are related to stimulation per se and not to a microthalamotomy effect. Journal of neurology, 250(6), pp. 707-13. Heidelberg: Springer-Medizin-Verlag 10.1007/s00415-003-1067-3

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The aim of this study was to investigate the impact of unilateral deep brain stimulation (DBS) of the ventrointermediate (Vim) thalamic nucleus on neuropsychological functioning comparing stimulation-on with stimulation-off conditions. Nine patients [five patients with Parkinson's Disease (PD), two patients with essential tremor (ET) and 2 patients with multiple sclerosis (MS)] underwent comprehensive neuropsychological testing for cognitive functions, including general mental impairment, aphasia, agnosia, executive and constructional abilities, learning, memory, cognitive processing speed and attention as well as depression. The neuropsychological assessments were performed at least 6 months postoperatively (mean 9 months). Testing in the stimulation-on and stimulation-off condition was obtained within a period of 3 to 4 weeks. Unilateral DBS resulted in improvement of tremor in all patients. There were no significant differences between the stimulation-on and the stimulation-off condition with the exception of a decrement of word-recall in the short delay free-recall subtest of the Rey Auditory-Verbal Learning Test (RAVLT). Subgroup analysis indicated that the impairment in word-recall was related to left-sided thalamic stimulation. Our study confirms that chronic unilateral DBS is a safe method with regard to cognitive function. The subtle changes in episodic memory are related to stimulation per se and not to a microthalamotomy effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Gutbrod, Klemens and Burgunder, Jean-Marc

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-5354

ISBN:

12796834

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

30 Jan 2017 10:53

Publisher DOI:

10.1007/s00415-003-1067-3

PubMed ID:

12796834

Web of Science ID:

000183459400011

URI:

https://boris.unibe.ch/id/eprint/28383 (FactScience: 120487)

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