The immune geography of IgA induction and function

Macpherson, A J; McCoy, K D; Johansen, F-E; Brandtzaeg, P (2008). The immune geography of IgA induction and function. Mucosal immunology, 1(1), pp. 11-22. New York, N.Y.: Nature Publishing Group 10.1038/mi.2007.6

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The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is mostly exported across mucous membranes. The discovery of IgA and the realization that it dominates humoral mucosal immunity, in contrast to the IgG dominance of the systemic immune system, was early evidence for the distinct nature of mucosal immunology. It is now clear that IgA can function in high-affinity modes for neutralization of toxins and pathogenic microbes, and as a low-affinity system to contain the dense commensal microbiota within the intestinal lumen. The basic map of induction of IgA B cells in the Peyer's patches, which then circulate through the lymph and bloodstream to seed the mucosa with precursors of plasma cells that produce dimeric IgA for export through the intestinal epithelium, has been known for more than 30 years. In this review, we discuss the mechanisms underlying selective IgA induction of mucosal B cells for IgA production and the immune geography of their homing characteristics. We also review the functionality of secretory IgA directed against both commensal organisms and pathogens.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Macpherson, Andrew

ISSN:

1933-0219

ISBN:

19079156

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

17 Mar 2015 22:20

Publisher DOI:

10.1038/mi.2007.6

PubMed ID:

19079156

Web of Science ID:

000260408400004

URI:

https://boris.unibe.ch/id/eprint/28393 (FactScience: 120514)

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