Respiratory muscle activity related to flow and lung volume in preterm infants compared with term infants

Hutten, Gerard J; van Eykern, Leo A; Latzin, Philipp; Thamrin, Cindy; van Aalderen, Wim M; Frey, Urs (2010). Respiratory muscle activity related to flow and lung volume in preterm infants compared with term infants. Pediatric research, 68(4), pp. 339-43. New York, N.Y.: Nature Publishing Group 10.1203/PDR.0b013e3181eeeaf4

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Infants with chronic lung disease (CLD) have a capacity to maintain functional lung volume despite alterations to their lung mechanics. We hypothesize that they achieve this by altering breathing patterns and dynamic elevation of lung volume, leading to differences in the relationship between respiratory muscle activity, flow and lung volume. Lung function and transcutaneous electromyography of the respiratory muscles (rEMG) were measured in 20 infants with CLD and in 39 healthy age-matched controls during quiet sleep. We compared coefficient of variations (CVs) of rEMG and the temporal relationship of rEMG variables, to flow and lung volume [functional residual capacity (FRC)] between these groups. The time between the start of inspiratory muscle activity and the resulting flow (tria)--in relation to respiratory cycle time--was significantly longer in infants with CLD. Although FRC had similar associations with tria and postinspiratory activity (corrected for respiratory cycle time), the CV of the diaphragmatic rEMG was lower in CLD infants (22.6 versus 31.0%, p = 0.030). The temporal relationship of rEMG to flow and FRC and the loss of adaptive variability provide additional information on coping mechanisms in infants with CLD. This technique could be used for noninvasive bedside monitoring of CLD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Latzin, Philipp; Thamrin, Cindy and Frey, Urs Peter

ISSN:

0031-3998

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

06 Dec 2013 13:23

Publisher DOI:

10.1203/PDR.0b013e3181eeeaf4

PubMed ID:

20606599

Web of Science ID:

000282074100013

URI:

https://boris.unibe.ch/id/eprint/2840 (FactScience: 205762)

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