Lateralization of dynorphin gene expression in the rat striatum

Capper-Loup, Christine; Kaelin-Lang, Alain (2008). Lateralization of dynorphin gene expression in the rat striatum. Neuroscience letters, 447(2-3), pp. 106-8. Amsterdam: Elsevier 10.1016/j.neulet.2008.09.071

Full text not available from this repository. (Request a copy)

Hemispheric lateralization is well known in the cerebral cortex, but not in subcortical structures like basal ganglia. The goal of our study was to determine whether lateralization was present in the direct and indirect striatal pathways. We studied gene expression in the striatum of healthy rats, which was divided into two sectors, medial and lateral. Dynorphin (DYN) and enkephalin (ENK) mRNA were analyzed as markers of the direct and indirect striatal pathways, respectively and glutamic acid decarboxylase (GAD) mRNA was analyzed as a marker of all medium spiny neurons. DYN and GAD mRNA expression was higher on the left hemisphere in the medial sector of the striatum, but not in the lateral one. We did not observe any difference between sides with ENK mRNA expression. We suggest the presence of a lateralization in the medial striatum, which is specific for the direct striatal pathway.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Capper, Christine and Kaelin, Alain

ISSN:

0304-3940

ISBN:

18838109

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1016/j.neulet.2008.09.071

PubMed ID:

18838109

Web of Science ID:

000261549300002

URI:

https://boris.unibe.ch/id/eprint/28400 (FactScience: 120542)

Actions (login required)

Edit item Edit item
Provide Feedback