Nyffeler, Thomas; Pierrot-Deseilligny, Charles; Felblinger, Jaques; Mosimann, Urs P; Hess, Christian W; Müri, René M (2002). Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study. European journal of neuroscience, 16(9), pp. 1823-7. Oxford: Blackwell Science 10.1046/j.1460-9568.2002.02252.x
Full text not available from this repository.The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation significantly increased in both delays the percentage of error in amplitude (PEA) of contralateral memory-guided saccades compared to the control experiment without stimulation. dTMS applied late in the delay had no significant effect on PEA. Furthermore, we found a significantly smaller effect of early stimulation in the long-delay paradigm. These results suggest a time-dependent hierarchical organization of the spatial working memory with a functional dominance of DLPFC during the early memorization, independent from the memorization delay. For a long memorization delay, however, working memory seems to have an additional, DLPFC-independent component.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Nyffeler, Thomas, Hess, Christian Walter |
ISSN: |
0953-816X |
ISBN: |
12431236 |
Publisher: |
Blackwell Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:05 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1046/j.1460-9568.2002.02252.x |
PubMed ID: |
12431236 |
Web of Science ID: |
000179240000022 |
URI: |
https://boris.unibe.ch/id/eprint/28436 (FactScience: 120739) |
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