Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study

Nyffeler, Thomas; Pierrot-Deseilligny, Charles; Felblinger, Jaques; Mosimann, Urs P; Hess, Christian W; Müri, René M (2002). Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study. European journal of neuroscience, 16(9), pp. 1823-7. Oxford: Blackwell Science 10.1046/j.1460-9568.2002.02252.x

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The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation significantly increased in both delays the percentage of error in amplitude (PEA) of contralateral memory-guided saccades compared to the control experiment without stimulation. dTMS applied late in the delay had no significant effect on PEA. Furthermore, we found a significantly smaller effect of early stimulation in the long-delay paradigm. These results suggest a time-dependent hierarchical organization of the spatial working memory with a functional dominance of DLPFC during the early memorization, independent from the memorization delay. For a long memorization delay, however, working memory seems to have an additional, DLPFC-independent component.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Nyffeler, Thomas and Hess, Christian Walter

ISSN:

0953-816X

ISBN:

12431236

Publisher:

Blackwell Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1046/j.1460-9568.2002.02252.x

PubMed ID:

12431236

Web of Science ID:

000179240000022

URI:

https://boris.unibe.ch/id/eprint/28436 (FactScience: 120739)

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