Deep brain stimulation for dystonia: outcome at long-term follow-up

Loher, T J; Capelle, H-H; Kaelin-Lang, A; Weber, S; Weigel, R; Burgunder, J M; Krauss, J K (2008). Deep brain stimulation for dystonia: outcome at long-term follow-up. Journal of neurology, 255(6), pp. 881-4. Heidelberg: Springer-Medizin-Verlag 10.1007/s00415-008-0798-6

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OBJECTIVE: Deep brain stimulation (DBS) has emerged as a useful therapeutic option for patients with insufficient benefit from conservative treatment. METHODS: Nine patients with chronic DBS who suffered from cervical dystonia (4), generalized dystonia (2), hemidystonia (1), paroxysmal dystonia (1) and Meige syndrome (1) were available for formal follow-up at three years postoperatively, and beyond up to 10 years. All patients had undergone pallidal stimulation except one patient with paroxysmal dystonia who underwent thalamic stimulation. RESULTS: Maintained improvement was seen in all patients with pallidal stimulation up to 10 years after surgery except in one patient who had a relative loss of benefit in dystonia ratings but continued to have improved disability scores. After nine years of chronic thalamic stimulation there was a mild loss of efficacy which was regained when the target was changed to the pallidum in the patient with paroxysmal dystonia. There were no major complications related to surgery or to chronic stimulation. Pacemakers had to be replaced within 1.5 to 2 years, in general. CONCLUSION: DBS maintains marked long-term symptomatic and functional improvement in the majority of patients with dystonia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kaelin, Alain; Weber, Simone and Burgunder, Jean-Marc

ISSN:

0340-5354

ISBN:

18338193

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1007/s00415-008-0798-6

PubMed ID:

18338193

Web of Science ID:

000257629900016

URI:

https://boris.unibe.ch/id/eprint/28446 (FactScience: 120813)

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