Expression of adenosine A2a receptors gene in the olfactory bulb and spinal cord of rat and mouse

Kaelin-Lang, A; Lauterburg, T; Burgunder, J M (1999). Expression of adenosine A2a receptors gene in the olfactory bulb and spinal cord of rat and mouse. Neuroscience letters, 261(3), pp. 189-91. Amsterdam: Elsevier 10.1016/S0304-3940(99)00022-1

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The expression of adenosine A2a receptors (A2aR) in the mammalian striatum is well known. In contrast the exact distribution of A2aR in other regions of the central nervous system remains unclear. The aim of this study was to investigate the A2aR gene expression in the rat olfactory bulb and spinal cord, two regions which are seldom included in mapping studies. Secondly, we compared the A2aR expression in the rat and in the mouse brain. Hybridization histochemistry was performed with an S35-labelled radioactive oligonucleotide probe. The results show strong expression of A2aR in the mouse and rat striatum in accordance with previous reports. In the olfactory bulb a weak but specific expression of A2aR was found in the granular cell layer in both species. In contrast, no significant expression of the A2aR gene was observed in other parts of the brain or the rat spinal cord. The presence of the A2aR in the mammalian olfactory bulb suggests a functional role for this receptor in olfaction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kaelin, Alain

ISSN:

0304-3940

ISBN:

10081981

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1016/S0304-3940(99)00022-1

PubMed ID:

10081981

Web of Science ID:

000079155000016

URI:

https://boris.unibe.ch/id/eprint/28449 (FactScience: 120819)

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