MicroRNAs: a new class of regulatory genes affecting metabolism

Krützfeldt, Jan; Stoffel, Markus (2006). MicroRNAs: a new class of regulatory genes affecting metabolism. Cell metabolism, 4(1), pp. 9-12. Cambridge, Mass.: Cell Press 10.1016/j.cmet.2006.05.009

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MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression by binding to target mRNAs, which leads to reduced protein synthesis and sometimes decreased steady-state mRNA levels. Although hundreds of miRNAs have been identified, much less is known about their biological function. Several studies have provided evidence that miRNAs affect pathways that are fundamental for metabolic control in higher organisms such as adipocyte and skeletal muscle differentiation. Furthermore, some miRNAs have been implicated in lipid, amino acid, and glucose homeostasis. These studies open the possibility that miRNAs may contribute to common metabolic diseases and point to novel therapeutic opportunities based on targeting of miRNAs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Krützfeldt, Jan

ISSN:

1550-4131

ISBN:

16814728

Publisher:

Cell Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

17 Mar 2015 22:20

Publisher DOI:

10.1016/j.cmet.2006.05.009

PubMed ID:

16814728

Web of Science ID:

000238821800005

URI:

https://boris.unibe.ch/id/eprint/28591 (FactScience: 121975)

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