Krützfeldt, Jan; Stoffel, Markus (2006). MicroRNAs: a new class of regulatory genes affecting metabolism. Cell metabolism, 4(1), pp. 9-12. Cambridge, Mass.: Cell Press 10.1016/j.cmet.2006.05.009
Full text not available from this repository. (Request a copy)MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression by binding to target mRNAs, which leads to reduced protein synthesis and sometimes decreased steady-state mRNA levels. Although hundreds of miRNAs have been identified, much less is known about their biological function. Several studies have provided evidence that miRNAs affect pathways that are fundamental for metabolic control in higher organisms such as adipocyte and skeletal muscle differentiation. Furthermore, some miRNAs have been implicated in lipid, amino acid, and glucose homeostasis. These studies open the possibility that miRNAs may contribute to common metabolic diseases and point to novel therapeutic opportunities based on targeting of miRNAs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Krützfeldt, Jan |
ISSN: |
1550-4131 |
ISBN: |
16814728 |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:06 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1016/j.cmet.2006.05.009 |
PubMed ID: |
16814728 |
Web of Science ID: |
000238821800005 |
URI: |
https://boris.unibe.ch/id/eprint/28591 (FactScience: 121975) |
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