Strategies to determine the biological function of microRNAs

Krützfeldt, Jan; Poy, Matthew N; Stoffel, Markus (2006). Strategies to determine the biological function of microRNAs. Nature genetics, 38 Suppl, S14-S19. New York, N.Y.: Nature America 10.1038/ng1799

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MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression profiling and target gene validation, as well as manipulation of miRNA expression in vivo, will facilitate the study of their contribution to biological processes and disease. Such information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Krützfeldt, Jan

ISSN:

1061-4036

ISBN:

16736018

Publisher:

Nature America

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

08 Jun 2016 10:49

Publisher DOI:

10.1038/ng1799

PubMed ID:

16736018

Web of Science ID:

000202983200004

URI:

https://boris.unibe.ch/id/eprint/28592 (FactScience: 121977)

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