Mullis, (2010). Biological determinants of responsiveness to growth hormone: pharmacogenomics and personalized medicine. Endocrine development, 18, pp. 67-82. Basel: Karger
Full text not available from this repository. (Request a copy)It is becoming most clear that many genes are involved in controlling the regulation of growth. Ultimately however, at the level of growth hormone (GH), the relevant question may be not whether a patient is GH-deficient, but whether he is GH-responsive. As these disturbances can be divided into two gross categories, namely alterations causing subnormal GH secretion and/or those presenting with subnormal GH sensitivity/responsiveness, the main aim of this review is to focus on genes involved in growth regulation leading to short stature caused by an alteration of GH insensitivity/GH responsiveness; in other words, clinical circumstances where individually adapted GH replacement therapy may help to increase height velocity and eventually final height.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Mullis, Primus-Eugen |
ISSN: |
1421-7082 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:13 |
Last Modified: |
05 Dec 2022 14:02 |
PubMed ID: |
20523018 |
URI: |
https://boris.unibe.ch/id/eprint/2864 (FactScience: 205797) |
Actions (login required)
 |
Edit item |