Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis

Grandgirard, Denis; Loeffler, Jutta M.; Fischetti, Vincent A.; Leib, Stephen L. (2008). Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis. Journal of infectious diseases, 197(11), pp. 1519-1522. Cary, N.C.: The University of Chicago Press 10.1086/587942

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Treatment of bacterial meningitis caused by Streptococcus pneumoniae is increasingly difficult, because of emerging resistance to antibiotics. Recombinant Cpl-1, a phage lysin specific for S. pneumoniae, was evaluated for antimicrobial therapy in experimental pneumococcal meningitis using infant Wistar rats. A single intracisternal injection (20 mg/kg) of Cpl-1 resulted in a rapid (within 30 min) decrease in pneumococci in cerebrospinal fluid (CSF) by 3 orders of magnitude lasting for 2 h. Intraperitoneal administration of Cpl-1 (200 mg/kg) led to an antibacterial effect in CSF of 2 orders of magnitude for 3 h. Cpl-1 may hold promise as an alternative treatment option in pneumococcal meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Grandgirard, Denis and Leib, Stephen

ISSN:

0022-1899

ISBN:

18471063

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

24 Oct 2019 22:03

Publisher DOI:

10.1086/587942

PubMed ID:

18471063

Web of Science ID:

000255748500007

BORIS DOI:

10.7892/boris.28669

URI:

https://boris.unibe.ch/id/eprint/28669 (FactScience: 125110)

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