Structural and metabolic changes in language areas linked to formal thought disorder

Horn, Helge; Federspiel, Andrea; Wirth, Miranka; Müller, Thomas J; Wiest, Roland; Wang, Jiong-Jiong; Strik, Werner (2009). Structural and metabolic changes in language areas linked to formal thought disorder. British journal of psychiatry, 194(2), pp. 130-8. London: Royal College of Psychiatrists 10.1192/bjp.bp.107.045633

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BACKGROUND: The role of the language network in the pathophysiology of formal thought disorder has yet to be elucidated. AIMS: To investigate whether specific grey-matter deficits in schizophrenic formal thought disorder correlate with resting perfusion in the left-sided language network. METHOD: We investigated 13 right-handed patients with schizophrenia and formal thought disorder of varying severity and 13 matched healthy controls, using voxel-based morphometry and magnetic resonance imaging perfusion measurement (arterial spin labelling). RESULTS: We found positive correlations between perfusion and the severity of formal thought disorder in the left frontal and left temporoparietal language areas. We also observed bilateral deficits in grey-matter volume, positively correlated with the severity of thought disorder in temporoparietal areas and other brain regions. The results of the voxel-based morphometry and the arterial spin labelling measurements overlapped in the left posterior superior temporal gyrus and left angular gyrus. CONCLUSIONS: Specific grey-matter deficits may be a risk factor for state-related dysfunctions of the left-sided language system, leading to local hyperperfusion and formal thought disorder.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Horn, Helge Joachim; Federspiel, Andrea; Wirth, Miranka; Müller, Thomas Jörg; Wiest, Roland and Strik, Werner

ISSN:

0007-1250

ISBN:

19182174

Publisher:

Royal College of Psychiatrists

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1192/bjp.bp.107.045633

PubMed ID:

19182174

Web of Science ID:

000263338300007

URI:

https://boris.unibe.ch/id/eprint/28779 (FactScience: 130196)

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