Intrarenal resistance index for the assessment of early renal function impairment in patients with liver cirrhosis

Götzberger, M; Kaiser, C; Landauer, N; Dieterle, C; Heldwein, W; Schiemann, U (2008). Intrarenal resistance index for the assessment of early renal function impairment in patients with liver cirrhosis. European journal of medical research, 13(8), pp. 383-7. München: I. Holzapfel

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BACKGROUND: Renovascular vasoconstriction in patients with hepatorenal syndrome can be quantified by the renal arterial resistance index (RI). We investigated the value of RI measurement in detection of renal function impairment in patients with different stages of chronic liver disease. METHODS: Subjects were divided into 4 groups containing 21 patients with liver cirrhosis and ascites, 25 patients with liver cirrhosis without ascites, 35 patients with fatty liver disease and 78 control subjects. All patients underwent abdominal ultrasound examination with renal RI measurement and correlation with laboratory results for renal function. RESULTS: RI was significantly higher in ascitic patients compared to non-ascitic patients (0.74 vs. 0.67, p<0.01) and in non-ascitic patients with liver cirrhosis than in control subjects (0.67 vs. 0.62, p<0.01). 48% (19/40) of patients with liver cirrhosis and normal serum creatinine concentration showed elevated RI levels. There were no significant differences in RI levels between patients with fatty liver disease and controls (0.63 vs. 0.62). CONCLUSIONS: Intrarenal RI measurement is a predictor of renal vasoconstriction and serves to detect early renal function impairment in cirrhotic patients. The diagnosis of elevated RI may be taken into account in the clinical management of these patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

?? DCD5A442B9C7E17DE0405C82790C4DE2 ??

UniBE Contributor:

Schiemann, Uwe Kurt

ISSN:

0949-2321

ISBN:

18952521

Publisher:

I. Holzapfel

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

04 May 2014 23:21

PubMed ID:

18952521

Web of Science ID:

000259009100005

URI:

https://boris.unibe.ch/id/eprint/28986 (FactScience: 132883)

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