Longitudinal platelet reactivity to acute psychological stress among older men and women

Aschbacher, Kirstin; von Kanel, Roland; Mills, Paul; Roepke, Susan; Hong, Suzi; Dimsdale, Joel; Mausbach, Brent; Patterson, Thomas; Ziegler, Michael; Ancoli-Israel, Sonia; Grant, Igor (2009). Longitudinal platelet reactivity to acute psychological stress among older men and women. Stress - the international journal on the biology of stress, 12(5), pp. 426-33. Reading: Taylor & Francis 10.1080/10253890802046281

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Platelet reactivity to acute stress is associated with increased cardiovascular disease risk; however, little research exists to provide systematic methodological foundations needed to generate strong longitudinal research designs. Study objectives were: 1) to evaluate whether markers of platelet function increase in response to an acute psychological stress test among older adults, 2) to establish whether reactivity remains robust upon repeated administration (i.e. three occasions approximately 1 year apart), and 3) to evaluate whether two different acute speech stress tasks elicit similar platelet responses. The 149 subjects (mean age 71 years) gave a brief impromptu speech on one of two randomly assigned topics involving interpersonal conflict. Blood samples drawn at baseline and post-speech were assayed using flow cytometry for platelet responses on three outcomes (% aggregates, % P-selectin expression, and % fibrinogen receptor expression). Three-level hierarchical linear modeling analyses revealed significant stress-induced increases in platelet activation on all outcomes (p < 0.001). No significant habituation on any measure was found. Additional reactivity differences were associated with male gender, history of myocardial infarction, and use of aspirin, statins, and antidepressants. The results demonstrate that laboratory acute stress tests continued to produce robust platelet reactivity on three activation markers among older adults over 3 years.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland




Taylor & Francis




Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

04 May 2014 23:21

Publisher DOI:


PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/28999 (FactScience: 132926)

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