Connexin 43 expression in human hypertrophied heart due to pressure and volume overload

Vetter, Christian; Zweifel, Martin; Zuppinger, Christian; Carrel, Thierry; Martin, David; Haefliger, Jacques-Antoine; Delacrétaz, Etienne (2010). Connexin 43 expression in human hypertrophied heart due to pressure and volume overload. Physiological research / Academia Scientiarum Bohemoslovaca, 59(1), pp. 35-42. Praha: Academia Scientiarum Bohemoslovaca

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Left ventricular hypertrophy (LVH) is due to pressure overload or mechanical stretch and is thought to be associated with remodeling of gap-junctions. We investigated whether the expression of connexin 43 (Cx43) is altered in humans in response to different degrees of LVH. The expression of Cx43 was analyzed by quantitative polymerase chain reaction, Western blot analysis and immunohistochemistry on left ventricular biopsies from patients undergoing aortic or mitral valve replacement. Three groups were analyzed: patients with aortic stenosis with severe LVH (n=9) versus only mild LVH (n=7), and patients with LVH caused by mitral regurgitation (n=5). Cx43 mRNA expression and protein expression were similar in the three groups studied. Furthermore, immunohistochemistry revealed no change in Cx43 distribution. We can conclude that when compared with mild LVH or with LVH due to volume overload, severe LVH due to chronic pressure overload is not accompanied by detectable changes of Cx43 expression or spatial distribution.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Zweifel, Martin; Zuppinger, Christian; Carrel, Thierry and Delacrétaz, Etienne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0862-8408

Publisher:

Academia Scientiarum Bohemoslovaca

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

19 Jan 2015 22:00

PubMed ID:

19249908

Web of Science ID:

000276097000005

BORIS DOI:

10.7892/boris.29

URI:

https://boris.unibe.ch/id/eprint/29 (FactScience: 191510)

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