[Bilateral surgical lung volume reduction in severe emphysema]

Demertzis, S; Schäfers, H J; Wagner, T O; Hausen, B; Fabel, H; Borst, H G (1996). [Bilateral surgical lung volume reduction in severe emphysema]. Deutsche medizinische Wochenschrift, 14(121), 427-32; discussion 433. Stuttgart: Thieme 10.1055/s-2008-1043022

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OBJECTIVE: To report preliminary results with a new surgical method of treating terminal emphysema by bilateral reduction of lung volume. PATIENTS AND METHODS: In a prospective study, the results obtained with the first 20 consecutive patients (mean FEV1: 590 +/- 180 ml) who underwent operative reduction of lung volume were recorded. 19 of the 20 patients had required continuous oxygen supply. RESULTS: The patients were extubated 8.5 +/- 6 h postoperatively; thoracic drainage was removed after 9 +/- 6 days. The degree of dyspnoea was decreased in all patients (3.5 +/- 0.5 vs 0.5 +/- 0.1). Significant reduction of overinflation occurred soon after the operation (residual volume 273 +/- 125 to 201 +/- 107% of normal; total capacity from 142 +/- 18 to 109 +/- 22% of normal), as well as reduction in the degree of obstruction (FEV1 from 18 +/- 6 to 24 +/- 7% of normal; for each, P < 0.05). One patient died 3 weeks post-operatively of Candida infection. CONCLUSION: The method looks promising for the treatment of selected patients and may thus provide an alternative to lung transplantation.

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Journal Article (Further Contribution)


04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Demertzis, Stefanos










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Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

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https://boris.unibe.ch/id/eprint/29679 (FactScience: 157826)

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