Tricuspid valve regurgitation attributable to endomyocardial biopsies and rejection in heart transplantation

Hausen, B; Albes, J M; Rohde, R; Demertzis, S; Mügge, A; Schäfers, H J (1995). Tricuspid valve regurgitation attributable to endomyocardial biopsies and rejection in heart transplantation. Annals of thoracic surgery, 5(59), pp. 1134-40. New York, N.Y.: Elsevier 10.1016/0003-4975(95)00089-4

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In the present report the prevalence, severity, and risk factors of tricuspid valve regurgitation (TR) in 251 heart transplant recipients have been analyzed retrospectively. Tricuspid valve function was studied by color-flow Doppler echocardiogram and annual heart catheterization. The presence or severity of TR was graded on a scale from 0 (no TR) to 4 (severe). Additional postoperative data included rate of rejection, number of endomyocardial biopsies, incidence of transplant vasculopathy, and preoperative and postoperative hemodynamics. The incidence of grade 3 TR increases from 5% at 1 year to 50% at 4 years after transplantation. Multivariate analysis showed rate of rejection and donor heart weight to be significant risk factors. The ischemic intervals as well as the preoperative and postoperative pulmonary hemodynamics did not affect the severity or prevalence of TR. These results indicate that various factors appear to have an impact on the development of TR and that the prevalence might be lowered by a reduction of the number of biopsies performed and when possible, oversizing of donor hearts.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Demertzis, Stefanos










Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

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URI: (FactScience: 157842)

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