University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation

Demertzis, S; Wippermann, J; Schaper, J; Wahlers, T; Schäfers, H J; Wagenbreth, I; Hausen, B; Haverich, A (1993). University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation. Annals of thoracic surgery, 5(55), pp. 1131-7. New York, N.Y.: Elsevier 10.1016/0003-4975(93)90019-E

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Prolongation of the safe period of ischemia of the heart is an efficient way to overcome donor organ shortage, as demonstrated in renal and hepatic transplantation. We present the results of a prospective, randomized study comparing preservation with University of Wisconsin solution (UWS) versus St. Thomas' Hospital solution (STS) in clinical heart transplantation. A total of 39 patients were enrolled in the study (n = 20 for UWS and n = 19 for STS). Hemodynamic, electron microscopic, and biochemical evaluation did not reveal any significant differences in postoperative myocardial performance. Only the number of intraoperative defibrillations (0.82 for UWS versus 1.7 for STS) and the rhythm stability after reperfusion (13/20 UWS hearts versus 6/19 STS hearts in sinus rhythm) were significantly different. Heart preservation with UWS and STS appears to be of comparable efficacy at mean ischemic times of less than 4 hours.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Demertzis, Stefanos

ISSN:

0003-4975

ISBN:

8494421

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

Publisher DOI:

10.1016/0003-4975(93)90019-E

PubMed ID:

8494421

Web of Science ID:

A1993LD13000015

URI:

https://boris.unibe.ch/id/eprint/29700 (FactScience: 157868)

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