Preoperative corticosteroids. A contraindication to lung transplantation?

Schäfers, H J; Wagner, T O; Demertzis, S; Hamm, M; Wahlers, T; Cremer, J; Haverich, A (1992). Preoperative corticosteroids. A contraindication to lung transplantation? Chest, 5(102), pp. 1522-5. Northbrook, Ill.: American College of Chest Physicians 10.1378/chest.102.5.1522

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Regular preoperative application of corticosteroids has been considered as a contraindication to lung transplantation for fear of an increased risk of postoperative morbidity and mortality. Recently, however, we have accepted patients for transplantation in whom treatment with steroid medication could not be terminated preoperatively. Up to February 1991, 27 unilateral and bilateral transplantations in 26 patients were analyzed. Corticosteroid therapy was discontinued at least three months prior to transplantation in 13 patients (group 1), whereas in 14 cases, the patients continued their daily corticosteroid therapy to the time of transplantation (prednisolone, 0.1 to 0.3 mg/kg/day; group 2). There were no significant differences between the groups with respect to sex, age, diagnosis, or type of transplantation. One limited bronchial dehiscence occurred; the incidence of postoperative bronchial stenosis was identical in both cohorts; one patient died in each group. In conclusion, no increased morbidity or mortality could be found following lung transplantation with regular preoperative administration of prednisolone up to 0.3 mg/kg/day. Thus, patients who cannot be weaned from their steroid medication but who otherwise are acceptable candidates should not be excluded from lung transplantation.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine
UniBE Contributor:	Demertzis, Stefanos
ISSN:	0012-3692
ISBN:	1424876
Publisher:	American College of Chest Physicians
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:08
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.1378/chest.102.5.1522
PubMed ID:	1424876
Web of Science ID:	A1992JX20900044
URI:	https://boris.unibe.ch/id/eprint/29704 (FactScience: 157876)