Growth of lung allografts after experimental transplantation

Dammenhayn, L; Haverich, A; Demertzis, S; Reimer, P; Kemnitz, J (1991). Growth of lung allografts after experimental transplantation. Thoracic and cardiovascular surgeon, 1(39), pp. 40-3. Stuttgart: Thieme 10.1055/s-2007-1013928

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Heart and lung transplantation has been performed in cases of end-stage cardiopulmonary disease in infants. Nevertheless, it still remains unclear whether lung allografts adjust to a growing organism. In 6 young domestic pigs unilateral left lung allotransplantation was performed. Immunosuppression consisted of a triple drug therapy including cyclosporine, azathioprine, and corticosteroids. Lung growth was studied by using bronchography, pulmonary angiography, and lung histology. After 11 weeks the transplanted animals had doubled their body weight from 24 kg to 48 kg. Non-transplanted animals in contrast doubled their weight within only 6 weeks. The growth retardation was attributed to the immunosuppressive therapy. The bronchial tree and pulmonary vasculature of lung allografts showed a similar growth potential to non-transplanted lungs in animals of equivalent body weight. In one case of recurrent severe rejection of the lung no growth was observed. Therefore it was concluded that lung allografts grow adequately according to the development of the recipient organism. Lung transplantation in children does not seem to be restricted by a limited growth potential of the graft.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine
UniBE Contributor:	Demertzis, Stefanos
ISSN:	0171-6425
ISBN:	2011847
Publisher:	Thieme
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:08
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.1055/s-2007-1013928
PubMed ID:	2011847
Web of Science ID:	A1991EY06100008
URI:	https://boris.unibe.ch/id/eprint/29710 (FactScience: 157888)