Musical Training Induces Functional Plasticity in Human Hippocampus

Herdener, Marcus; Esposito, Fabrizio; di Salle, Francesco; Boller, Christian; Hilti, Caroline Claudia; Habermeyer, Benedikt; Scheffler, Klaus; Wetzel, Stephan; Seifritz, Erich; Cattapan-Ludewig, Katja (2010). Musical Training Induces Functional Plasticity in Human Hippocampus. Journal of neuroscience, 30(4), pp. 1377-1384. Washington, D.C.: Society for Neuroscience 10.1523/JNEUROSCI.4513-09.2010

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Training can change the functional and structural organization of the brain, and animal models demonstrate that the hippocampus formation is particularly susceptible to training-related neuroplasticity. In humans, however, direct evidence for functional plasticity of the adult hippocampus induced by training is still missing. Here, we used musicians' brains as a model to test for plastic capabilities of the adult human hippocampus. By using functional magnetic resonance imaging optimized for the investigation of auditory processing, we examined brain responses induced by temporal novelty in otherwise isochronous sound patterns in musicians and musical laypersons, since the hippocampus has been suggested previously to be crucially involved in various forms of novelty detection. In the first cross-sectional experiment, we identified enhanced neural responses to temporal novelty in the anterior left hippocampus of professional musicians, pointing to expertise-related differences in hippocampal processing. In the second experiment, we evaluated neural responses to acoustic temporal novelty in a longitudinal approach to disentangle training-related changes from predispositional factors. For this purpose, we examined an independent sample of music academy students before and after two semesters of intensive aural skills training. After this training period, hippocampal responses to temporal novelty in sounds were enhanced in musical students, and statistical interaction analysis of brain activity changes over time suggests training rather than predisposition effects. Thus, our results provide direct evidence for functional changes of the adult hippocampus in humans related to musical training.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

Hilti, Caroline Claudia; Seifritz, Erich and Cattapan-Ludewig, Katja

ISSN:

0270-6474

Publisher:

Society for Neuroscience

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

13 Dec 2014 05:04

Publisher DOI:

10.1523/JNEUROSCI.4513-09.2010

PubMed ID:

20107063

Web of Science ID:

000274050000018

BORIS DOI:

10.7892/boris.2990

URI:

https://boris.unibe.ch/id/eprint/2990 (FactScience: 206084)

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