Impaired performance on the rapid visual information processing task (RVIP) could be an endophenotype of schizophrenia

Hilti, Caroline Claudia; Hilti, Leonie Maria; Heinemann, Dörthe; Robbins, Trevor; Seifritz, Erich; Cattapan-Ludewig, Katja (2010). Impaired performance on the rapid visual information processing task (RVIP) could be an endophenotype of schizophrenia. Psychiatry research, 177(1-2), pp. 60-4. Amsterdam: Elsevier 10.1016/j.psychres.2009.12.012

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The aim of the present study was to investigate whether healthy first-degree relatives of schizophrenia patients show reduced sensitivity performance, higher intra-individual variability (IIV) in reaction time (RT), and a steeper decline in sensitivity over time in a sustained attention task. Healthy first-degree relatives of schizophrenia patients (n=23) and healthy control subjects (n=46) without a family history of schizophrenia performed a demanding version of the Rapid Visual Information Processing task (RVIP). RTs, hits, false alarms, and the sensitivity index A' were assessed. The relatives were significantly less sensitive, tended to have higher IIV in RT, but sustained the impaired level of sensitivity over time. Impaired performance on the RVIP is a possible endophenotype for schizophrenia. Higher IIV in RT, apparently caused by impaired context representations, might result in fluctuations in control and lead to more frequent attentional lapses.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Hilti, Caroline Claudia; Heinemann, Dörthe; Seifritz, Erich and Cattapan-Ludewig, Katja

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0165-1781

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

03 Mar 2014 01:36

Publisher DOI:

10.1016/j.psychres.2009.12.012

PubMed ID:

20110130

Web of Science ID:

000278278800011

URI:

https://boris.unibe.ch/id/eprint/2991 (FactScience: 206085)

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