Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean?

Noti, Mario; Sidler, Daniel; Brunner, Thomas (2009). Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Seminars in immunopathology, 31(2), pp. 237-48. Berlin: Springer-Verlag 10.1007/s00281-009-0159-2

[img]
Preview
Text
281_2009_Article_159.pdf - Published Version
Available under License Publisher holds Copyright.

Download (337kB) | Preview

Glucocorticoids (GC) are lipophilic hormones commonly used as therapeutics in acute and chronic inflammatory disorders such as inflammatory bowel disease due to their attributed anti-inflammatory and immunosuppressive actions. Although the adrenal glands are the major source of endogenous GC, there is increasing evidence for the production of extra-adrenal GC in the brain, thymus, skin, vasculature, and the intestine. However, the physiological relevance of extra-adrenal-produced GC remains still ambiguous. Therefore, this review attracts attention to discuss possible biological benefits of extra-adrenal-synthesized GC, especially focusing on the impact of locally synthesized GC in the regulation of intestinal immune responses.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Noti, Mario; Sidler, Daniel and Brunner, Thomas

ISSN:

1863-2297

ISBN:

19495759

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

24 Aug 2020 16:54

Publisher DOI:

10.1007/s00281-009-0159-2

PubMed ID:

19495759

Web of Science ID:

000269863300008

BORIS DOI:

10.7892/boris.29970

URI:

https://boris.unibe.ch/id/eprint/29970 (FactScience: 165543)

Actions (login required)

Edit item Edit item
Provide Feedback