First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

Serduc, Raphaël; Bräuer-Krisch, Elke; Bouchet, Audrey; Renaud, Luc; Brochard, Thierry; Bravin, Alberto; Laissue, Jean Albert; Le Duc, Géraldine (2009). First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy. Journal of synchrotron radiation, 16(Pt 4), pp. 587-90. Oxford: Blackwell Publishing 10.1107/S0909049509012485

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The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Laissue, Jean

ISSN:

0909-0495

ISBN:

19535875

Publisher:

Blackwell Publishing

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

Publisher DOI:

10.1107/S0909049509012485

PubMed ID:

19535875

Web of Science ID:

000267047100020

URI:

https://boris.unibe.ch/id/eprint/30014 (FactScience: 165770)

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