Hodgkin lymphoma in the Swiss HIV Cohort Study

Clifford, Gary M; Rickenbach, Martin; Lise, Mauro; Dal Maso, Luigino; Battegay, Manuel; Bohlius, Julia; Boffi El Amari, Emmanuelle; Karrer, Urs; Jundt, Gernot; Bordoni, Andrea; Ess, Silvia; Franceschi, Silvia (2009). Hodgkin lymphoma in the Swiss HIV Cohort Study. Blood, 113(23), pp. 5737-42. Washington, D.C.: American Society of Hematology 10.1182/blood-2009-02-204172

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Hodgkin lymphoma (HL) risk is elevated among persons infected with HIV (PHIV) and has been suggested to have increased in the era of combined antiretroviral therapy (cART). Among 14,606 PHIV followed more than 20 years in the Swiss HIV Cohort Study (SHCS), determinants of HL were investigated using 2 different approaches, namely, a cohort and nested case-control study, estimating hazard ratios (HRs) and matched odds ratios, respectively. Forty-seven incident HL cases occurred during 84,611 person-years of SHCS follow-up. HL risk was significantly higher among men having sex with men (HR vs intravenous drug users = 2.44, 95% confidence interval [CI], 1.13-5.24) but did not vary by calendar period (HR for 2002-2007 vs 1995 or earlier = 0.65, 95% CI, 0.29-1.44) or cART use (HR vs nonusers = 1.02, 95% CI, 0.53-1.94). HL risk tended to increase with declining CD4(+) cell counts, but these differences were not significant. A lower CD4(+)/CD8(+) ratio at SHCS enrollment or 1 to 2 years before HL diagnosis, however, was significantly associated with increased HL risk. In conclusion, HL risk does not appear to be increasing in recent years or among PHIV using cART in Switzerland, and there was no evidence that HL risk should be increased in the setting of improved immunity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Bohlius, Julia

ISSN:

0006-4971

ISBN:

19336755

Publisher:

American Society of Hematology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:09

Last Modified:

23 Jun 2015 14:59

Publisher DOI:

10.1182/blood-2009-02-204172

PubMed ID:

19336755

Web of Science ID:

000266656100012

BORIS DOI:

10.7892/boris.30203

URI:

https://boris.unibe.ch/id/eprint/30203 (FactScience: 191380)

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