Schlapbach, Christoph; Yawalkar, Nikhil; Hunger, Robert E (2009). Human beta-defensin-2 and psoriasin are overexpressed in lesions of acne inversa. Journal of the American Academy of Dermatology, 61(1), pp. 58-65. New York, N.Y.: Elsevier 10.1016/j.jaad.2008.12.033
Full text not available from this repository.BACKGROUND: Acne inversa is a chronic inflammatory disorder of apocrine gland-bearing skin. The role of the innate immune system in the pathogenesis of the disease is controversial. OBJECTIVES: We investigated the expression of antimicrobial peptide/proteins in acne inversa. METHODS: Tissue samples were obtained from patients with acne inversa and compared with normal-appearing skin. The expression of psoriasin and human beta-defensin (hBD)-2 on messenger RNA and protein level was analyzed. RESULTS: Both messenger RNA and protein levels of psoriasin and hBD-2 were significantly increased in acne inversa. Macrophages expressing hBD-2 were found in the dermis. LIMITATIONS: Small sample size is a limitation. CONCLUSIONS: Antimicrobial peptide/proteins are overexpressed in acne inversa lesions as compared with normal-appearing skin. The site of the major expression depends on the particular antimicrobial peptide/protein. Psoriasin is overexpressed in epidermal keratinocytes whereas hBD-2 is produced mainly by dermal macrophages, leaving a relative deficiency of hBD-2 in the epidermis of acne inversa lesions.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Yawalkar, Nikhil, Hunger, Robert |
ISSN: |
0190-9622 |
ISBN: |
19249126 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:09 |
Last Modified: |
05 Dec 2022 14:21 |
Publisher DOI: |
10.1016/j.jaad.2008.12.033 |
PubMed ID: |
19249126 |
Web of Science ID: |
000267325000009 |
URI: |
https://boris.unibe.ch/id/eprint/30398 (FactScience: 193776) |
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