Parametric estimation of pulse arrival time: a robust approach to pulse wave velocity

Solà, Josep; Vetter, Rolf; Renevey, Philippe; Chételat, Olivier; Sartori, Claudio; Rimoldi, Stefano F (2009). Parametric estimation of pulse arrival time: a robust approach to pulse wave velocity. Physiological measurement, 30(7), pp. 603-615. Bristol, UK: Institute of Physics Publishing IOP 10.1088/0967-3334/30/7/006

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Pulse wave velocity (PWV) is a surrogate of arterial stiffness and represents a non-invasive marker of cardiovascular risk. The non-invasive measurement of PWV requires tracking the arrival time of pressure pulses recorded in vivo, commonly referred to as pulse arrival time (PAT). In the state of the art, PAT is estimated by identifying a characteristic point of the pressure pulse waveform. This paper demonstrates that for ambulatory scenarios, where signal-to-noise ratios are below 10 dB, the performance in terms of repeatability of PAT measurements through characteristic points identification degrades drastically. Hence, we introduce a novel family of PAT estimators based on the parametric modeling of the anacrotic phase of a pressure pulse. In particular, we propose a parametric PAT estimator (TANH) that depicts high correlation with the Complior(R) characteristic point D1 (CC = 0.99), increases noise robustness and reduces by a five-fold factor the number of heartbeats required to obtain reliable PAT measurements.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Rimoldi, Stefano




Institute of Physics Publishing IOP




Factscience Import

Date Deposited:

04 Oct 2013 15:09

Last Modified:

05 Dec 2022 14:21

Publisher DOI:


PubMed ID:


Web of Science ID:


URI: (FactScience: 194556)

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